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KMID : 0882420080750050564
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Korean Journal of Medicine
2008 Volume.75 No. 5 p.564 ~ p.568
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A case of acute drug-induced hepatotoxicity after albendazole treatment
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Kim Min-Kwan
Park Hye-Won
Kim Won-Jin
Park Chul-Min
Hong Ji-Yeon
Cho Seong-Jin
Jang Myung-Kook
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Abstract
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Drug-induced hepatotoxicity is injury to the liver as a result of drug exposure. Due to their unpredictable nature, drug-induced liver injuries pose a serious problem for clinicians, health agencies, and pharmaceutical firms. Albendazole
is a benzimidazole with wide spectrum coverage as an antiparasitic drug. Very few cases of high-dose albendazoleinduced hepatotoxicity have been reported so far, and no case in response to a single dose. A 25-year-old man presented to our hospital with dark urine. Twenty days prior to presentation, he took a tablet of albendazole (400 mg) as a prophylactic treatment for lumbricosis. Upon laboratory analysis, aspartate aminotransferase (AST) was 748 IU/L, alanine transaminase (ALT) was 939 IU/L, and total/direct bilirubin was 9.3/7.3 mg/dL. The patient was negative for viral markers (HAV, HBV, and HCV) and autoantibodies. Abdominal ultrasonography revealed no evidence of chronic liver damage. The pathology was compatible with drug-induced hepatotoxicity. The patient improved with conservative management only.
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KEYWORD
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Albendazole, Hepatotoxicity
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